# Morphology-to-molecule matching leaderboard

Knowledge benchmark

> Every figure below is reproduced as its upstream source published it: nothing is modelled, estimated, interpolated or converted. `Unavailable` means no source published the value — it is never a zero. Each value carries its evidence state and the date it was observed.

Page: https://modelscale.dev/leaderboards/benchmarks/knowledge-morphology-to-molecule

Axiom Bio morphology-to-molecule matching. Every model the catalog carries a published Morphology-to-molecule matching value for, ranked by that value.

## Benchmark record

| Field | Value |
| --- | --- |
| Category | Knowledge |
| Measure | Matching accuracy |
| Tasks | Four multi-channel cell-imaging perturbation-matching tasks |
| Difficulty | Biomedical image and molecular reasoning |
| Published by | [Claude Opus 5.5 System Card](https://www-cdn.anthropic.com/fc1b44717c85dc068bc6ba5024219938094694bd/Claude%20Opus%205.5%20System%20Card.pdf) |

Matches multi-channel cellular imaging data to the molecule-dose perturbations that produced it.

## Morphology-to-molecule matching ranking

2 models with a published Morphology-to-molecule matching value, ordered by that value, highest first. Models the source has not scored on this benchmark are not listed — they are unmeasured, not last.

| Rank | Model | Provider | Matching accuracy | Evidence |
| --- | --- | --- | --- | --- |
| 1 | [Claude Opus 5.5](https://modelscale.dev/models/claude-opus-5-5) | Anthropic | 34.0 | Observed 2026-10-23 · source benchlm:models |
| 2 | [Claude Sonnet 5.5](https://modelscale.dev/models/claude-sonnet-5-5) | Anthropic | 25.0 | Observed 2026-10-23 · source benchlm:models |

Rows are ordered by the value the source published, highest first. The source does not state whether a higher value is the better result, so this document does not either: for a benchmark that measures a rate of failure, read the table from the bottom.