# De novo protein-binder design leaderboard

Knowledge benchmark

> Every figure below is reproduced as its upstream source published it: nothing is modelled, estimated, interpolated or converted. `Unavailable` means no source published the value — it is never a zero. Each value carries its evidence state and the date it was observed.

Page: https://modelscale.dev/leaderboards/benchmarks/knowledge-protein-binder-design

Anthropic de novo protein-binder design evaluation. Every model the catalog carries a published De novo protein-binder design value for, ranked by that value.

## Benchmark record

| Field | Value |
| --- | --- |
| Category | Knowledge |
| Measure | Composite structural design score |
| Tasks | 15 protein targets |
| Difficulty | Long-horizon computational protein design |
| Published by | [Claude Opus 5.5 System Card](https://www-cdn.anthropic.com/fc1b44717c85dc068bc6ba5024219938094694bd/Claude%20Opus%205.5%20System%20Card.pdf) |

Designs diverse miniprotein binders against target protein structures in a GPU-equipped research sandbox.

## De novo protein-binder design ranking

2 models with a published De novo protein-binder design value, ordered by that value, highest first. Models the source has not scored on this benchmark are not listed — they are unmeasured, not last.

| Rank | Model | Provider | Composite structural design score | Evidence |
| --- | --- | --- | --- | --- |
| 1 | [Claude Opus 5.5](https://modelscale.dev/models/claude-opus-5-5) | Anthropic | 82.6 | Observed 2026-10-23 · source benchlm:models |
| 2 | [Claude Sonnet 5.5](https://modelscale.dev/models/claude-sonnet-5-5) | Anthropic | 82.3 | Observed 2026-10-23 · source benchlm:models |

Rows are ordered by the value the source published, highest first. The source does not state whether a higher value is the better result, so this document does not either: for a benchmark that measures a rate of failure, read the table from the bottom.