Knowledge benchmark
Protein Design leaderboard
Anthropic Protein Design evaluation. Every model the catalog carries a published Protein Design value for, ranked by that value.
CategoryKnowledge
MeasureComposite score
TasksConstrained protein-sequence design tasks
DifficultyComputational protein design
Published byClaude Opus 5 System Card
Generates novel protein sequences under family, topology, globularity, and structural-motif constraints.
Protein Design ranking
1 model with a published Protein Design value, ordered by that value, highest first. Models the source has not scored on this benchmark are not listed — they are unmeasured, not last.
| Rank | Model | Provider | Composite score |
|---|---|---|---|
| 1 |  Claude Opus 5 | Anthropic | 42.5 |
Evidence key: Observed
Rows are ordered by the value Claude Opus 5 System Card published, highest first. The source does not state whether a higher value is the better result, so this page does not either: for a benchmark that measures a rate of failure, read the table from the bottom.