Knowledge benchmark
ProteinGym Hard leaderboard
Every model the catalog carries a published ProteinGym Hard value for, ranked by that value.
CategoryKnowledge
MeasureRank correlation
TasksHard protein mutation-effect ranking tasks
DifficultyComputational protein science
Published byClaude Opus 5 System Card
Predicts mutation effects by ranking mutant protein sequences against wild type and comparing against laboratory measurements.
ProteinGym Hard ranking
1 model with a published ProteinGym Hard value, ordered by that value, highest first. Models the source has not scored on this benchmark are not listed — they are unmeasured, not last.
| Rank | Model | Provider | Rank correlation |
|---|---|---|---|
| 1 |  Claude Opus 5 | Anthropic | 47.7 |
Evidence key: Observed
Rows are ordered by the value Claude Opus 5 System Card published, highest first. The source does not state whether a higher value is the better result, so this page does not either: for a benchmark that measures a rate of failure, read the table from the bottom.